Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.
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Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.
The growing appreciation of the active interface between the immune system and the nervous system includes recognition of the cell surface molecules and the transducing mechanisms that are shared between the two systems. Perhaps even more compelling is the identification of intercellular messengers that mediate active signaling between the two systems. Neurotransmitters and neuropeptides, well ...
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The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is en...
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15 صفحه اولInvestigation of Leptin, Leukemia Inhibitory Factor (LIF), and IL-6 Serum Levels in Myeloid Leukemia
Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia p...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.17.7833